Sulfuric Acid → 3-(3',4'-Dichloro-4-biphenylyl)-3-hydroxybutyric acid ethyl ester

HRID 26909ノート

反応式

HRID 26909 の反応式
Br[CH2:2][C:3]([O:5][CH2:6][CH3:7])=[O:4].[C:8]([C:11]1[CH:16]=[CH:15][C:14]([C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[C:19]([Cl:24])[CH:18]=2)=[CH:13][CH:12]=1)(=[O:10])[CH3:9].S(=O)(=O)(O)O>[Zn].C1C=CC=CC=1>[CH2:6]([O:5][C:3](=[O:4])[CH2:2][C:8]([C:11]1[CH:16]=[CH:15][C:14]([C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[C:19]([Cl:24])[CH:18]=2)=[CH:13][CH:12]=1)([OH:10])[CH3:9])[CH3:7]

参加物

6

反応物 3

HCID 1118Sulfuric AcidHCID 7748Ethyl bromoacetateHCID 167688151-[4-(3,4-Dichlorophenyl)phenyl]ethan-1-one

生成物 1

HCID 544122843-(3',4'-Dichloro-4-biphenylyl)-3-hydroxybutyric acid ethyl ester

試薬・触媒・溶媒 2

HCID 23994Zinc触媒HCID 241Benzene溶媒

実験手順

A mixture of 20 g. of ethyl bromoacetate, 26.5 g. of 4-acetyl-3',4'-dichlorobiphenyl and 8 g. of zinc foil is added to 100 ml. of benzene and the mixture is stirred and heated under reflux for one hour. It is cooled and dilute sulfuric acid is added to decompose the alcoholate obtained. The organic phase is separated off and, after the customary work up, 3-(3',4'-dichloro-4-biphenylyl)-3-hydroxybutyric acid ethyl ester is obtained.

後処理

  1. additionA mixture of 20 g
  2. temperatureheated
  3. temperatureunder reflux for one hour
  4. temperatureIt is cooled
  5. customobtained
  6. customThe organic phase is separated off

出典と根拠

ORDレコード
ord-4e1f0da971e1426899736fcb4ac4bc66
出典データセット
uspto-grants-1979_04
特許番号
US04151302

反応ノート

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