Water → 3-(2',4'-Difluoro-4-biphenylyl)butyric acid

反応式

[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12]([CH:15]([CH3:19])[CH2:16][C:17]#N)=[CH:11][CH:10]=1.C([OH:26])CCCCC.OS(O)(=O)=O.[OH2:32]>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12]([CH:15]([CH3:19])[CH2:16][C:17]([OH:26])=[O:32])=[CH:11][CH:10]=1

参加物

反応物 4

HCID 962Water

HCID 1118Sulfuric Acid

HCID 81031-Hexanol

HCID 213225213-(2',4'-Difluoro-4-biphenylyl)butyronitrile

生成物 1

HCID 213225403-(2',4'-Difluoro-4-biphenylyl)butyric acid

実験手順

1 g. of 3-(2',4'-difluoro-4-biphenylyl)butyronitrile, 3 ml. of n-hexanol and 0.1 g. of concentrated H2SO4 are heated under reflux for 48 hours. 3 ml. of water are added and the mixture is heated under reflux for 48 hours more and worked up in the customary manner to give 3-(2',4'-difluoro-4-biphenylyl)-butyric acid, m.p. 109°-110°.