Water → 3-(2',4'-Difluoro-4-biphenylyl)butyric acid

HRID 26932

反応式

HRID 26932 の反応式
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12]([CH:15]([CH3:19])[CH2:16][C:17]#N)=[CH:11][CH:10]=1.C([OH:26])CCCCC.OS(O)(=O)=O.[OH2:32]>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12]([CH:15]([CH3:19])[CH2:16][C:17]([OH:26])=[O:32])=[CH:11][CH:10]=1

参加物

5

反応物 4

HCID 962WaterHCID 1118Sulfuric AcidHCID 81031-HexanolHCID 213225213-(2',4'-Difluoro-4-biphenylyl)butyronitrile

生成物 1

HCID 213225403-(2',4'-Difluoro-4-biphenylyl)butyric acid

実験手順

1 g. of 3-(2',4'-difluoro-4-biphenylyl)butyronitrile, 3 ml. of n-hexanol and 0.1 g. of concentrated H2SO4 are heated under reflux for 48 hours. 3 ml. of water are added and the mixture is heated under reflux for 48 hours more and worked up in the customary manner to give 3-(2',4'-difluoro-4-biphenylyl)-butyric acid, m.p. 109°-110°.

後処理

  1. temperatureunder reflux for 48 hours
  2. temperaturethe mixture is heated
  3. temperatureunder reflux for 48 hours more

出典と根拠

ORDレコード
ord-ac0eb0931272464d9cce0fa5ac820a65
出典データセット
uspto-grants-1979_04
特許番号
US04151302

関連ノート

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