Sodium Hydroxide → 6-Chloro-1H-pyrrolo[2,3-b]pyridine
反応式
C(OC([N:6]1[C:10]2=[N:11][C:12]([Cl:15])=[CH:13][CH:14]=[C:9]2[CH:8]=[CH:7]1)=O)C.[OH-].[Na+]>CO>[Cl:15][C:12]1[N:11]=[C:10]2[NH:6][CH:7]=[CH:8][C:9]2=[CH:14][CH:13]=1参加物
4
実験手順
To a solution of 6-Chloro-pyrrolo[2,3-b]pyridine-1-carboxylic acid ethyl ester (400 mg, 1.78 mmol) in MeOH (35 mL) was added 1N NaOH (13 mL). The solution was stirred at RT for 6 h and evaporated the solvent. The residue was neutralized with sat. NaHCO3 and the resulting precipitate was collected by filtration. After washing with water, the solid was dried on the pump for direct use (260 mg, 1.71 mmol, 96%). MS (ES+): m/e=153.1 (M+H); LC: 2.85 min.
後処理
- customevaporated the solvent
- filtrationthe resulting precipitate was collected by filtration
- washAfter washing with water
- customthe solid was dried on the pump for direct use (260 mg, 1.71 mmol, 96%)
- custom2.85 min.
出典と根拠
- ORDレコード
- ord-e51b2f56ff3b4963b8f2d3fb914b04ed
- 出典データセット
- uspto-grants-2008_11
- 特許番号
- US07446199B2
反応ノート
読み込み中…