Water → 2-Benzyloxy-[1,1';2',1'']terphenyl-3''-carboxylic acid

HRID 269538ノート

反応式

HRID 269538 の反応式
C([O:3][C:4]([C:6]1[CH:7]=[C:8]([C:12]2[C:13]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[O:24][CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:9]=[CH:10][CH:11]=1)=[O:5])C.[OH-].[Na+].O>C(O)C>[CH2:25]([O:24][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=1[C:13]1[C:12]([C:8]2[CH:9]=[CH:10][CH:11]=[C:6]([C:4]([OH:5])=[O:3])[CH:7]=2)=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1

参加物

5

反応物 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 587309952-Benzyloxy-[1,1';2',1'']terphenyl-3''-carboxylic acid ethyl ester

生成物 1

HCID 103623772-Benzyloxy-[1,1';2',1'']terphenyl-3''-carboxylic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
50 °C

実験手順

2-Benzyloxy-[1,1′;2′,1″]terphenyl-3″-carboxylic acid ethyl ester (84 mg, 0.206 mmol) was dissolved in ethanol (2 ml) and 2M sodium hydroxide (0.5 ml) added. The mixture was stirred and heated to 50° C. for 4 h. Water was added and the mixture extracted with isohexane. The aqueous layer was acidified with 2M hydrochloric acid and extracted with diethyl ether (2×10 ml). The combined organic phases were washed with water, dried (MgSO4) and evaporated. The oil was triturated with isohexane and the resulting white solid filtered, washed with isohexane and dried in vacuo. (42 mg, 54%).

後処理

  1. extractionthe mixture extracted with isohexane
  2. extractionextracted with diethyl ether (2×10 ml)
  3. washThe combined organic phases were washed with water
  4. dry with materialdried (MgSO4)
  5. customevaporated
  6. customThe oil was triturated with isohexane
  7. filtrationthe resulting white solid filtered
  8. washwashed with isohexane
  9. customdried in vacuo

出典と根拠

ORDレコード
ord-d92563337723441e9c318ae746aa1691
出典データセット
uspto-grants-2008_11
特許番号
US07446222B2

反応ノート

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