tert-Butanol → 1,1-Dimethylethyl 3-bromo-5-iodobenzoate

HRID 269556

反応式

HRID 269556 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([I:11])[CH:10]=1)[C:5]([OH:7])=[O:6].Cl.CN(C)CCCC(N=C=N)C.[C:24](O)([CH3:27])([CH3:26])[CH3:25]>CN(C)C1C=CN=CC=1.ClCCl>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([I:11])[CH:10]=1)[C:5]([O:7][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:6]

参加物

6

反応物 3

HCID 6386tert-ButanolHCID 51825203-Bromo-5-iodobenzoic acidHCID 219829211-(3-Dimethylaminopropyl)ethylcarbodiimide hydrochloride

生成物 1

HCID 574859731,1-Dimethylethyl 3-bromo-5-iodobenzoate

試薬・触媒・溶媒 2

HCID 142844-(Dimethylamino)pyridine触媒HCID 6344Dichloromethane溶媒

実験手順

A mixture of 3-bromo-5-iodobenzoic acid (50 g, 153 mmol), 1-(3-dimethylaminopropyl)-ethylcarbodiimide hydrochloride (30.8 g, 153 mmol), 4-dimethylaminopyridine (18.6 g, 153 mmol) and t-butanol (69.4 g, 90 ml, 153 mmol) in dichloromethane (500 ml) was stirred at room temperature overnight. The reaction mixture was washed with 2MHCl and saturated NaHCO3. The organic phase was dried and evaporated to give the title compound as a light brown solid. (48 g; 85%).

後処理

  1. washThe reaction mixture was washed with 2MHCl and saturated NaHCO3
  2. customThe organic phase was dried
  3. customevaporated

出典と根拠

ORDレコード
ord-9d41c9fb650b4654bde723322a0a2f97
出典データセット
uspto-grants-2008_11
特許番号
US07446222B2

関連ノート

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