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Diisopropylethylamine → 9h-fluoren-9-ylmethyl{(1S)-4-amino-1-[({(2s)-2,5-bis[(tert-butoxycarbonyl)amino]pentyl}amino)carbonyl]-4-oxobutyl}carbamate

HRID 269650
ノート
印刷プレビュー

反応式

HRID 269650 の反応式
CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.C(N(CC)C(C)C)(C)C.[CH:34]1[C:46]2[CH:45]([CH2:47][O:48][C:49]([NH:51][C@H:52]([C:58](O)=[O:59])[CH2:53][CH2:54][C:55](=[O:57])[NH2:56])=[O:50])[C:44]3[C:39](=[CH:40][CH:41]=[CH:42][CH:43]=3)[C:38]=2[CH:37]=[CH:36][CH:35]=1.[C:61]([O:65][C:66](=[O:82])[NH:67][CH2:68][CH2:69][CH2:70][C@H:71]([NH:74][C:75]([O:77][C:78]([CH3:81])([CH3:80])[CH3:79])=[O:76])[CH2:72][NH2:73])([CH3:64])([CH3:63])[CH3:62]>CN(C=O)C>[CH:43]1[C:44]2[CH:45]([CH2:47][O:48][C:49](=[O:50])[NH:51][C@H:52]([C:58]([NH:73][CH2:72][C@@H:71]([NH:74][C:75]([O:77][C:78]([CH3:81])([CH3:80])[CH3:79])=[O:76])[CH2:70][CH2:69][CH2:68][NH:67][C:66]([O:65][C:61]([CH3:63])([CH3:64])[CH3:62])=[O:82])=[O:59])[CH2:53][CH2:54][C:55]([NH2:56])=[O:57])[C:46]3[C:38](=[CH:37][CH:36]=[CH:35][CH:34]=3)[C:39]=2[CH:40]=[CH:41][CH:42]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 81531DiisopropylethylamineHCID 2724775N2-((9H-Fluoren-9-ylmethoxy)carbonyl)-L-glutamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 57440197tert-Butyl {(4S)-5-amino-4-[(tert-butoxycarbonyl)amino]pentyl}carbamate

生成物 1

HCID 70806689
9h-fluoren-9-ylmethyl{(1S)-4-amino-1-[({(2s)-2,5-bis[(tert-butoxycarbonyl)amino]pentyl}amino)carbonyl]-4-oxobutyl}carbamate

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

129 mg (0.34 mmol) of HATU and 133 mg (0.95 mmol) of N,N-diisopropylethylamine are added to a solution of 100 mg (0.27 mmol) of N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-glutamine and 112 mg (0.35 mmol) of tert-butyl{(4S)-5-amino-4-[(tert-butoxycarbonyl)amino]pentyl}carbamate (Example 86A) in 5 ml of anhydrous DMF at 0° C. The reaction mixture is stirred at RT for 15 h. The solvent is then evaporated and the residue is stirred with water, collected by filtration and dried under high vacuum.

後処理

  1. customThe solvent is then evaporated
  2. stirringthe residue is stirred with water
  3. filtrationcollected by filtration
  4. customdried under high vacuum

出典と根拠

ORDレコード
ord-81743811b6c4430b81ef7e79aebcb1cc
出典データセット
uspto-grants-2008_11
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07446102B2

反応ノート

読み込み中…

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