Benzyl[3-({2-[(tert-butoxycarbonyl)amino]ethyl}amino)-3-oxopropyl]carbamate → HCID 86619445、化合物
反応式
C(OC(=O)[NH:10][CH2:11][CH2:12][C:13]([NH:15][CH2:16][CH2:17][NH:18][C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])=[O:14])C1C=CC=CC=1>[Pd].C(O)C>[C:22]([O:21][C:19]([NH:18][CH2:17][CH2:16][NH:15][C:13](=[O:14])[CH2:12][CH2:11][NH2:10])=[O:20])([CH3:25])([CH3:23])[CH3:24]参加物
4
実験手順
80 mg of palladium on activated carbon (10%) are added to a mixture of 0.30 g (0.82 mmol) of the compound from Example 254A in 10 ml of ethanol, and the mixture is then hydrogenated under atmospheric pressure for 12 h. The reaction mixture is filtered through kieselguhr, and the filtrate is concentrated in vacuo and dried under high vacuum. The crude product is reacted without further purification.
後処理
- filtrationThe reaction mixture is filtered through kieselguhr
- concentrationthe filtrate is concentrated in vacuo
- customdried under high vacuum
- customThe crude product is reacted without further purification
出典と根拠
- ORDレコード
- ord-4cdc0a2603814763878ae61d8cd8cc04
- 出典データセット
- uspto-grants-2008_11
- 特許番号
- US07446102B2
反応ノート
読み込み中…