HCID 86624523、化合物 → HCID 86624524、化合物

HRID 269690ノート

反応式

HRID 269690 の反応式
C(OC(=O)[NH:10][CH2:11][C@H:12]([NH:26][C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])[C:13]([NH:15][CH2:16][CH2:17][NH:18][C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])=[O:14])C1C=CC=CC=1>[Pd].C(O)(=O)C.C(O)C.O>[NH2:10][CH2:11][C@@H:12]([C:13]([NH:15][CH2:16][CH2:17][NH:18][C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])=[O:14])[NH:26][C:27]([O:29][C:30]([CH3:31])([CH3:32])[CH3:33])=[O:28]

参加物

4

反応物 1

HCID 86624523HCID 86624523、化合物

生成物 1

HCID 86624524HCID 86624524、化合物

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 86584229Acetic acid ethanol water溶媒

実験手順

50 mg of palladium on activated carbon (10%) are added to a mixture of 0.41 g (0.847 mmol) of the compound from Example 260A in 80 ml of acetic acid/ethanol/water (4:1:1), and the mixture is then hydrogenated under atmospheric pressure for 12 h. The reaction mixture is filtered through kieselguhr, and the filtrate is concentrated in vacuo and dried under high vacuum. The crude product is reacted without further purification.

後処理

  1. filtrationThe reaction mixture is filtered through kieselguhr
  2. concentrationthe filtrate is concentrated in vacuo
  3. customdried under high vacuum
  4. customThe crude product is reacted without further purification

出典と根拠

ORDレコード
ord-c527f1d8356c45059f3c1a3f0bfc498b
出典データセット
uspto-grants-2008_11
特許番号
US07446102B2

反応ノート

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