1-Phenethylpiperazine → 1-(4-Benzyloxy-3-fluorophenyl)-4-(3-cyclohexylpropyl)piperazine

HRID 269896

反応式

HRID 269896 の反応式
BrC1C=CC(OC)=C(C)C=1.C1(CCN2CCNCC2)C=CC=CC=1.[CH2:25]([O:32][C:33]1[CH:38]=[CH:37][C:36](Br)=[CH:35][C:34]=1[F:40])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1.[CH:41]1([CH2:47][CH2:48][CH2:49][N:50]2[CH2:55][CH2:54][NH:53][CH2:52][CH2:51]2)[CH2:46][CH2:45][CH2:44][CH2:43][CH2:42]1>>[CH2:25]([O:32][C:33]1[CH:38]=[CH:37][C:36]([N:53]2[CH2:54][CH2:55][N:50]([CH2:49][CH2:48][CH2:47][CH:41]3[CH2:46][CH2:45][CH2:44][CH2:43][CH2:42]3)[CH2:51][CH2:52]2)=[CH:35][C:34]=1[F:40])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1

参加物

5

反応物 4

HCID 792141-PhenethylpiperazineHCID 6083154-Bromo-1-methoxy-2-methylbenzeneHCID 27373931-(3-Cyclohexylpropyl)piperazineHCID 187574911-(Benzyloxy)-4-bromo-2-fluorobenzene

生成物 1

HCID 231114151-(4-Benzyloxy-3-fluorophenyl)-4-(3-cyclohexylpropyl)piperazine収率 111.4%

実験手順

Production Example 9 was repeated except that 5-bromo-2-methoxytoluene and 1-(2-phenylethyl)piperazine were replaced with 1-benzyloxy-4-bromo-2-fluorobenzene (1.42 g) and 1-(3-cyclo-hexylpropyl)piperazine (1.28 g), respectively, to provide crude 1-(4-benzyloxy-3-fluorophenyl)-4-(3-cyclohexylpropyl)piperazine (2.31 g).

出典と根拠

ORDレコード
ord-c63e18e059fe474497463d85a52780e9
出典データセット
uspto-grants-2008_11
特許番号
US07449466B2

関連ノート

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