Phenethyl bromide → 1-(2-Cyclohexylethyl)-4-(2,5-difluoro-4-methoxyphenyl)piperazine

HRID 269923

反応式

HRID 269923 の反応式
Cl.Cl.COC1C=CC(N2CCNCC2)=CC=1.Br[CH2:18][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.[F:26][C:27]1[CH:32]=[C:31]([O:33][CH3:34])[C:30]([F:35])=[CH:29][C:28]=1[N:36]1[CH2:41][CH2:40][NH:39][CH2:38][CH2:37]1.CS(OCCC1CCCCC1)(=O)=O>>[CH:20]1([CH2:19][CH2:18][N:39]2[CH2:38][CH2:37][N:36]([C:28]3[CH:29]=[C:30]([F:35])[C:31]([O:33][CH3:34])=[CH:32][C:27]=3[F:26])[CH2:41][CH2:40]2)[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1

参加物

5

反応物 4

HCID 7666Phenethyl bromideHCID 27237001-(4-Methoxyphenyl)-piperazine, dihydrochlorideHCID 227231732-Cyclohexylethyl methylsulfonateHCID 231114921-(2,5-Difluoro-4-methoxyphenyl)piperazine

生成物 1

HCID 231114791-(2-Cyclohexylethyl)-4-(2,5-difluoro-4-methoxyphenyl)piperazine

実験手順

Production Example 1 was repeated except that 1-(4-methoxyphenyl)piperazine dihydrochloride and (2-bromoethyl)-benzene were replaced with 1-(2,5-difluoro-4-methoxyphenyl)-piperazine (342 mg) and 2-cyclohexylethyl methylsulfonate (309 mg), respectively, to provide crude 1-(2-cyclohexylethyl)-4-(2,5-difluoro-4-methoxyphenyl)piperazine (476 mg).

出典と根拠

ORDレコード
ord-67875280920946beabd45c1e37fa0c34
出典データセット
uspto-grants-2008_11
特許番号
US07449466B2

関連ノート

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