2-Amino-4-chlorophenol → 2-Acetylamino-4-chlorophenol

HRID 270071

反応式

HRID 270071 の反応式
[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[OH:9].[C:10](OC(=O)C)(=[O:12])[CH3:11]>CO>[Cl:8][C:6]1[CH:5]=[CH:4][C:3]([OH:9])=[C:2]([NH:1][C:10](=[O:12])[CH3:11])[CH:7]=1

参加物

4

反応物 2

HCID 72652-Amino-4-chlorophenolHCID 7918Acetic Anhydride

生成物 1

HCID 952582-Acetylamino-4-chlorophenol収率 80.8%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a suspension of 2-amino-4-chlorophenol (1.43 g, 10.0 mmol) in methanol was added acetic anhydride (0.945 mL, 10.0 mmol) and the reaction mixture was stirred at room temperature for 2 h. The volatiles were removed in vacuo to give the subtitled compound (1.5 g).

後処理

  1. customThe volatiles were removed in vacuo

出典と根拠

ORDレコード
ord-40c22dff81724e1d9b69e1626f222a07
出典データセット
uspto-grants-2008_11
特許番号
US07449475B2

関連ノート

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