Methyl Salicylate → N-Methylsalicylamide

HRID 270101

反応式

HRID 270101 の反応式
[C:1]([O:10]C)(=O)[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[OH:4].[CH3:12][NH2:13]>CO>[OH:4][C:3]1[CH:5]=[CH:6][CH:7]=[CH:8][C:2]=1[C:1]([NH:13][CH3:12])=[O:10]

参加物

4

反応物 2

HCID 4133Methyl SalicylateHCID 6329Methylamine

生成物 1

HCID 74624N-Methylsalicylamide収率 90.6%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of methyl salicylate (5.16 mL, 40 mmol) in methanol (10 mL) was added dropwise to aqueous 40% methylamine (18.1 mL, 210 mmol) at 0° C. After addition was complete the reaction mixture was kept on stirring at room temperature overnight. The volatiles were removed in vacuo to give the subtitled compound (5.48 g).

後処理

  1. additionAfter addition
  2. customThe volatiles were removed in vacuo

出典と根拠

ORDレコード
ord-6df448f464b946efb1c50dd83b17c1f4
出典データセット
uspto-grants-2008_11
特許番号
US07449475B2

関連ノート

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