Nitric Acid → 6-Nitrophthalide

HRID 27019

反応式

HRID 27019 の反応式
[N+:1]([O-:4])(O)=[O:2].CN(C)C1C=C(N(C)C)C=CC=1[C:16]1(C2C=CC(N(C)C)=CC=2)[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[C:18](=[O:19])[O:17]1>S(=O)(=O)(O)O>[N+:1]([C:22]1[CH:21]=[C:20]2[C:25]([CH2:16][O:17][C:18]2=[O:19])=[CH:24][CH:23]=1)([O-:4])=[O:2]

参加物

4

反応物 2

HCID 944Nitric AcidHCID 204408323-(2,4-Bis(dimethylamino)phenyl)-3-(4-(dimethylamino)phenyl)phthalide

生成物 1

HCID 2235846-Nitrophthalide

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒2 回

実験手順

Three portions of a mixture of concentrated nitric acid (0.6 ml. each portion) and concentrated sulfuric acid (0.66 ml. each portion) were added to a mixture of 3-(2,4-bis(dimethylamino)phenyl)-3-(4-(dimethylamino)phenyl)phthalide (4.17 g.) and concentrated sulfuric acid (20 ml.) with cooling. After each addition the temperature was allowed to rise to room temperature. The resulting mixture was poured onto ice and the resulting mixture was basified, affording 3-(2,4-bis(dimethylamino)phenyl)-3-(4-(dimethylamino)phenyl)-5 or 6-nitrophthalide (I: X=Y4 =(CH3)2N, Y2 =Z4 =Z7 =H, Z5 or Z6 =O2N and the other of Z5 or Z6 =H) or a mixture of both.

後処理

  1. temperaturewith cooling
  2. additionAfter each addition the temperature
  3. customto rise to room temperature
  4. additionThe resulting mixture was poured onto ice

出典と根拠

ORDレコード
ord-13d623aa37214a3c893bc9d4a7946938
出典データセット
uspto-grants-1980_09
特許番号
US04220357

関連ノート

読み込み中…