Dimethylcarbamoyl Chloride → 1-(N,N-Dimethylcarbamoyl)-4,5-dicyanoimidazole

反応式

O1CCOCC1.[C:7]([C:9]1[N:10]=[CH:11][NH:12][C:13]=1[C:14]#[N:15])#[N:8].C(N(CC)CC)C.[CH3:23][N:24]([CH3:28])[C:25](Cl)=[O:26]>>[CH3:23][N:24]([CH3:28])[C:25]([N:10]1[C:9]([C:7]#[N:8])=[C:13]([C:14]#[N:15])[N:12]=[CH:11]1)=[O:26]

参加物

反応物 4

HCID 6598Dimethylcarbamoyl Chloride

HCID 8471Triethylamine

HCID 312751,4-Dioxane

HCID 707294,5-Dicyanoimidazole

生成物 1

HCID 233434181-(N,N-Dimethylcarbamoyl)-4,5-dicyanoimidazole

実験手順

To 50 ml of dry 1,4-dioxane 6.0 g (0.05 mole) of 4,5-dicyanoimidazole, 5.0 g (0.05 mole) of triethylamine and 6.0 g (0.055 mole) of dimethylcarbamoyl chloride are added in succession at room temperature. This mixture is stirred and refluxed for 3 days, cooled to room temperature and evaporated to dryness. The residue is stirred in 50 ml of ethyl acetate and 50 ml water. The organic layer is separated, washed, dried and evaporated to give 8 g. (85%) of white product.