Water → 4-Azidobutyrophenone
反応式
Cl[CH2:2][CH2:3][CH2:4][C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)=[O:6].[N-:13]=[N+:14]=[N-:15].[Na+].O>CS(C)=O>[N:13]([CH2:2][CH2:3][CH2:4][C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)=[O:6])=[N+:14]=[N-:15]参加物
5
反応条件
- 温度
- 55 °C
実験手順
To a solution of 4-chloro-1-phenylbutan-1-one (26.4 mL, 164 mmol) in DMSO (200 mL) was added sodium azide (12.8 g, 197 mmol). The solution was warmed to 55° C. and stirred for 16 hours. The cooled mixture was then treated with water (600 mL) and extracted with ether (3×200 mL). The combined organics were washed with water (8×100 mL) and brine (100 mL) then dried over MgSO4 and concentrated to provide the product as an orange oil (30.7 g, 99%).
後処理
- extractionextracted with ether (3×200 mL)
- washThe combined organics were washed with water (8×100 mL) and brine (100 mL)
- dry with materialthen dried over MgSO4
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-253696dc1b55418da1f3a49de57430f7
- 出典データセット
- uspto-grants-2008_11
- 特許番号
- US07449486B2
反応ノート
読み込み中…