Diacetone Alcohol → 4-Hydroxy-4-methyl-pentan-2-one oxime
反応式
[OH:1][C:2]([CH3:8])([CH3:7])[CH2:3][C:4](=O)[CH3:5].Cl.[NH2:10][OH:11].C(=O)(O)[O-].[Na+]>O>[OH:1][C:2]([CH3:8])([CH3:7])[CH2:3][C:4](=[N:10][OH:11])[CH3:5]参加物
5
実験手順
A mixture of 4-hydroxy-4-methyl-2-pentanone (10.0 g, 85.7 mmole) and hydroxylamine hydrochloride (22.17 g, 343 mmole) in 90 ml of water was stirred vigorously at room temperature. To this solution was added slowly over a period of an hour solid sodium bicarbonate (26.8 g, 343 mmole). After 3 hours the reaction mixture was extracted with ethyl acetate (3×, 100 ml), dried (MgSO4) and evaporated under reduced pressure, to give the product as an oil. Yield 11.2 g
後処理
- extractionAfter 3 hours the reaction mixture was extracted with ethyl acetate (3×, 100 ml)
- dry with materialdried (MgSO4)
- customevaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-5ea092ec175b430aaa850965a685d7f9
- 出典データセット
- uspto-grants-2008_11
- 特許番号
- US07449581B2
反応ノート
読み込み中…