Piperazine → 1-(Piperazin-1-yl)propan-1-one hydrochloride

HRID 27087

反応式

HRID 27087 の反応式
[Cl:1]C([N:4]1[CH2:9][CH2:8][N:7]([C:10](=[O:13])[CH2:11][CH3:12])[CH2:6][CH2:5]1)=O.N1CCNCC1.C(N)(=O)CC>C1(C)C(C)=CC=CC=1.II>[ClH:1].[C:10]([N:7]1[CH2:8][CH2:9][NH:4][CH2:5][CH2:6]1)(=[O:13])[CH2:11][CH3:12]

参加物

6

反応物 3

HCID 4837PiperazineHCID 6578PropionamideHCID 143695204-Propanoylpiperazine-1-carbonyl chloride

生成物 1

HCID 130178291-(Piperazin-1-yl)propan-1-one hydrochloride

試薬・触媒・溶媒 2

HCID 807Iodine触媒HCID 7237O-Xylene溶媒

実験手順

The 1-chlorocarbonyl-4-propionylpiperazine used as starting material can be prepared as follows. Anhydrous piperazine (120 g.) and propionamide (m.p. 80° C., 102 g.) in anhydrous xylene (100 cm3) are heated under reflux for 48 hours in the presence of iodine (0.9 g.) to give 1-propionylpiperazine hydrochloride (153.0 g.), m.p. 165° C. 1-Propionylpiperazine is liberated from its hydrochloride by the action of an excess of ammonia in diethyl ether. The ammonium chloride formed is separated by filtration and the 1-propionylpiperazine is isolated by evaporation of the ether.

後処理

  1. customcan be prepared

出典と根拠

ORDレコード
ord-18f5dfb69f5b4bd8898f781342fac926
出典データセット
uspto-grants-1980_09
特許番号
US04220646

関連ノート

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