Aniline → N-phenylethene-1-sulfonamide
反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CCN(CC)CC.Cl[CH2:16][CH2:17][S:18](Cl)(=[O:20])=[O:19]>C1(C)C=CC=CC=1.CCOC(C)=O>[C:2]1([NH:1][S:18]([CH:17]=[CH2:16])(=[O:20])=[O:19])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1参加物
6
実験手順
Aniline (0.98 mL, 10.7 mmol) and Et3N (1.8 mL, 12.9 mmol) in toluene (25 mL) were treated with 2-chloro-1-ethanesulfonylchloride (1.1 mL, 10.5 mmol). The exothermic reaction was stirred for 14 hours at room temperature. After stirring, the solution was diluted with EtOAc and washed with HCl (˜10% aq. soln.). The organic layer concentrated and purified via flash column chromatography (4:1 hexane/EtOAc) to afford two lots of phenyl(vinylsulfonyl)amine.
後処理
- customThe exothermic reaction
- stirringAfter stirring
- washwashed with HCl (˜10% aq. soln.)
- concentrationThe organic layer concentrated
- custompurified via flash column chromatography (4:1 hexane/EtOAc)
出典と根拠
- ORDレコード
- ord-67e8cb5e915a4fa9a119b8f925cd448e
- 出典データセット
- uspto-grants-2008_11
- 特許番号
- US07452889B2
反応ノート
読み込み中…