Water → 6-(furan-2-yl)-9H-purin-2-amine

HRID 271256

反応式

HRID 271256 の反応式
COC1C=C(C=CC=1OC)C[NH:7][C:8]1[NH:9][C:10]([C:17]2[O:18][CH:19]=[CH:20][CH:21]=2)=[C:11]2[C:15]([N:16]=1)=[N:14][CH:13]=[N:12]2.O>C(O)(C(F)(F)F)=O>[O:18]1[CH:19]=[CH:20][CH:21]=[C:17]1[C:10]1[NH:9][C:8]([NH2:7])=[N:16][C:15]2[C:11]=1[N:12]=[CH:13][N:14]=2

参加物

4

反応物 2

HCID 962WaterHCID 178490976HCID 178490976、化合物

生成物 1

HCID 1785082476-(furan-2-yl)-9H-purin-2-amine収率 67.8%

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

A solution of N-(3,4-dimethoxybenzyl)-6-(2-furyl)-1H-purine-2-amine (194 mg, 0.55 mmol) in TFA (1 mL) was heated at 60° C. for 30 min, poured into water, extracted with EtOAc and the combined organic phase was dried (MgSO4), concentrated in vacuo and purified by chromatography (SiO2; 5% MeOH in EtOAc). The resulting yellow solid was dissolved in MeOH, treated with HCl (1-M in Et2O) and filtered to give the title compound (75 mg, 57%) as a yellow solid.

後処理

  1. extractionextracted with EtOAc
  2. dry with materialthe combined organic phase was dried (MgSO4)
  3. concentrationconcentrated in vacuo
  4. custompurified by chromatography (SiO2; 5% MeOH in EtOAc)
  5. dissolutionThe resulting yellow solid was dissolved in MeOH
  6. additiontreated with HCl (1-M in Et2O)
  7. filtrationfiltered

出典と根拠

ORDレコード
ord-cfb7ae7a87c14cc4bdd2c3575aa927f3
出典データセット
uspto-grants-2008_11
特許番号
US07452894B2

関連ノート

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