Triethylamine → 9-(4-tert-Butylphenylsulphonyl)-6-(2-furyl)-9H-purine-2-amine

HRID 271258

反応式

HRID 271258 の反応式
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[NH:14][C:13]([NH2:15])=[N:12][C:11]2[C:7]=1[N:8]=[CH:9][N:10]=2.[C:16]([C:20]1[CH:25]=[CH:24][C:23]([S:26](Cl)(=[O:28])=[O:27])=[CH:22][CH:21]=1)([CH3:19])([CH3:18])[CH3:17].CCN(CC)CC>C1COCC1.CN(C=O)C.O>[C:16]([C:20]1[CH:25]=[CH:24][C:23]([S:26]([N:10]2[CH:9]=[N:8][C:7]3[C:11]2=[N:12][C:13]([NH2:15])=[N:14][C:6]=3[C:2]2[O:1][CH:5]=[CH:4][CH:3]=2)(=[O:28])=[O:27])=[CH:22][CH:21]=1)([CH3:19])([CH3:17])[CH3:18]

参加物

7

反応物 3

HCID 8471TriethylamineHCID 1398824-t-Butylbenzenesulfonyl chlorideHCID 1785082476-(furan-2-yl)-9H-purin-2-amine

生成物 1

HCID 598350419-(4-tert-Butylphenylsulphonyl)-6-(2-furyl)-9H-purine-2-amine収率 53.3%

試薬・触媒・溶媒 3

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒HCID 8028Tetrahydrofuran溶媒

反応条件

温度
60 °C

実験手順

A solution of 6-(2-furyl)-1H-purine-2-amine (100 mg, 0.5 mmol) in THF (2 mL) and DMF (0.5 mL) was treated with 4-tert-butylbenzenesulphonyl chloride (116 mg, 0.5 mmol) and Et3N (69 μL, 0.6 mmol), heated at 60° C. for 2 h, cooled, diluted with water and the resulting solid filtered and washed with EtOAc to give the title compound (106 mg, 53%) as a cream solid.

後処理

  1. temperaturecooled
  2. filtrationthe resulting solid filtered
  3. washwashed with EtOAc

出典と根拠

ORDレコード
ord-9f7350dd144c4e8ab165d5d6335c9ddb
出典データセット
uspto-grants-2008_11
特許番号
US07452894B2

関連ノート

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