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Methyl Acrylate → Methyl 3-(2-amino-6-(2-furyl)-9H-purine-9-yl)propionate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl Acrylate | HCID 7294 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 6-(furan-2-yl)-9H-purin-2-amine | HCID 178508247 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | Methyl 3-(2-amino-6-(2-furyl)-9H-purine-9-yl)propionate | HCID 59834959 | 11.4% |
反応手順
A solution of 6-(2-furyl)-1H-purine-2-amine (0.70 g, 3.48 mmol) and K2CO3 (0.48 g, 3.48 mmol) in DMF (20 mL) was treated with methyl acrylate (3.3 g, 38.3 mmol), stirred for 40 h, diluted with EtOAc, filtered to remove polymeric acrylate, washed with water, dried (MgSO4), concentrated in vacuo and purified by chromatography [SiO2: EtOAc-heptane, (4:1)] to give the title compound (114 mg, 11%) as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07452894B2 |
| 出典データセット | uspto-grants-2008_11 |
| ORD ID | ord-3c35fbd01a794b259e7c22e35a4be0c5 |
| 出典メモ | uspto-grants-2008_11 |