反应详情

A solution of 6-(2-furyl)-1H-purine-2-amine (0.70 g, 3.48 mmol) and K2CO3 (0.48 g, 3.48 mmol) in DMF (20 mL) was treated with methyl acrylate (3.3 g, 38.3 mmol), stirred for 40 h, diluted with EtOAc, filtered to remove polymeric acrylate, washed with water, dried (MgSO4), concentrated in vacuo and purified by chromatography [SiO2: EtOAc-heptane, (4:1)] to give the title compound (114 mg, 11%) as a white solid.

1. filtrationfiltered
2. customto remove polymeric acrylate
3. washwashed with water
4. dry with materialdried (MgSO4)
5. concentrationconcentrated in vacuo
6. custompurified by chromatography [SiO2: EtOAc-heptane, (4:1)]