4-Aminotetrahydro-2H-pyran-4-carboxylic acid hydrochloride → (4-Aminooxan-4-yl)methanol

HRID 271293

反応式

HRID 271293 の反応式
[H-].[H-].[H-].[H-].[Li+].[Al+3].Cl.[NH2:8][C:9]1([C:15](O)=[O:16])[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1>C1COCC1>[NH2:8][C:9]1([CH2:15][OH:16])[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1

参加物

4

反応物 2

HCID 27344004-Aminotetrahydro-2H-pyran-4-carboxylic acid hydrochlorideHCID 21226445Aluminium lithium hydride

生成物 1

HCID 18316484(4-Aminooxan-4-yl)methanol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

(4-Amino-tetrahydropyran-4-yl)-methanol is prepared by adding LAH (99%, 1.2 g), portionwise, to a stirred mixture of 4-aminotetrahydropyran-4-carboxylic acid hydrochloride (2.0 g, 11.0 mmol) in THF (30 mL) at 0° C. Upon completion of addition, the reaction mixture is warmed to room temperature and stirred for 1 hour. The reaction mixture is cooled to 0° C. and cautiously quenched by the portionwise addition of Na2SO4.10H2O (4 g). The reaction mixture is diluted with ethyl acetate, warmed to room temperature, and filtered through Celite to give the desired product.

後処理

  1. custom(4-Amino-tetrahydropyran-4-yl)-methanol is prepared
  2. additionUpon completion of addition
  3. temperatureThe reaction mixture is cooled to 0° C.
  4. customcautiously quenched by the portionwise addition of Na2SO4.10H2O (4 g)
  5. additionThe reaction mixture is diluted with ethyl acetate
  6. temperaturewarmed to room temperature
  7. filtrationfiltered through Celite

出典と根拠

ORDレコード
ord-955178be882b404683e51d66c5fa93f9
出典データセット
uspto-grants-2008_11
特許番号
US07452895B2

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