Ammonium Hydroxide → HCID 58772836、化合物

HRID 271445ノート

反応式

HRID 271445 の反応式
Cl[C:2]1[N:7]2[C:8](=[O:11])[NH:9][N:10]=[C:6]2[C:5]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)=[C:4]([C:19]2[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=2)[N:3]=1.[OH-].[NH4+:27]>C1COCC1>[NH2:27][C:2]1[N:7]2[C:8](=[O:11])[NH:9][N:10]=[C:6]2[C:5]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)=[C:4]([C:19]2[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=2)[N:3]=1

参加物

4

反応物 2

HCID 14923Ammonium HydroxideHCID 587728405-chloro-7,8-bis(4-chlorophenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-3(2H)-one

生成物 1

HCID 58772836HCID 58772836、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a stirring solution of 5-chloro-7,8-bis(4-chlorophenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-3(2H)-one (120 mg, 0.31 mmol) in 3 mL THF, was added ammonium hydroxide (28% in water, 0.12 mL, 1.8 mmol). The reaction mixture was stirred at room temperature for 3 h and then concentrated under reduced pressure. The resulting crude title compound was used in the next step without further purification. HPLC/MS: retention time=3.60 min, [M+H]30 =372.

後処理

  1. concentrationconcentrated under reduced pressure
  2. customThe resulting crude title compound was used in the next step without further purification

出典と根拠

ORDレコード
ord-0015eea386804732b895b38851934da1
出典データセット
uspto-grants-2008_11
特許番号
US07452892B2

反応ノート

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