Potassium Carbonate → o-Cresol, 4-bromo-alpha,alpha,alpha-trifluoro-

HRID 271651ノート

反応式

HRID 271651 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8]C)=[C:4]([C:10]([F:13])([F:12])[F:11])[CH:3]=1.C([O-])([O-])=O.[K+].[K+]>Br.C(O)(=O)C.O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([C:10]([F:11])([F:12])[F:13])[CH:3]=1

参加物

6

反応物 2

HCID 11430Potassium CarbonateHCID 27753044-Bromo-1-methoxy-2-(trifluoromethyl)benzene

生成物 1

HCID 142784o-Cresol, 4-bromo-alpha,alpha,alpha-trifluoro-

試薬・触媒・溶媒 3

HCID 176Acetic Acid溶媒HCID 260Hydrogen Bromide溶媒HCID 962Water溶媒

実験手順

A solution of 3.0 g (11.8 mmol) 4-bromo-1-methoxy-2-trifluoromethyl-benzene in 20 mL 1 M HBr in glacial acetic acid is stirred for 60 h at 90° C. The reaction solution is diluted with 300 mL water, adjusted to pH 7 with K2CO3. The aqueous phase is extracted with EtOAc, the combined organic extracts are with washed 40 mL quarter-saturated NaHCO3 solution and dried over MgSO4. The solvent is eliminated i.vac. and the product is further reacted without any more purification.

後処理

  1. extractionThe aqueous phase is extracted with EtOAc
  2. washwith washed 40 mL quarter-saturated NaHCO3 solution
  3. dry with materialdried over MgSO4
  4. customand the product is further reacted without any more purification

出典と根拠

ORDレコード
ord-9bc6fed42f4d41b6ad20d5843bc30211
出典データセット
uspto-grants-2008_11
特許番号
US07452911B2

反応ノート

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