Hydrochloric Acid → 5-(4-Chloro-phenyl)-2-{4-[2-(4-isopropyl-piperidin-1-yl)-ethoxy]-3-methyl-phenylethynyl}-pyridine

HRID 271722

反応式

HRID 271722 の反応式
[CH:1]([CH:4]1[CH2:9][CH2:8][NH:7][CH2:6][CH2:5]1)([CH3:3])[CH3:2].Cl.CS(O[CH2:16][CH2:17][O:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]#[C:26][C:27]2[CH:32]=[CH:31][C:30]([C:33]3[CH:38]=[CH:37][C:36]([Cl:39])=[CH:35][CH:34]=3)=[CH:29][N:28]=2)=[CH:21][C:20]=1[CH3:40])(=O)=O.C(N(C(C)C)C(C)C)C>CN(C=O)C>[Cl:39][C:36]1[CH:37]=[CH:38][C:33]([C:30]2[CH:31]=[CH:32][C:27]([C:26]#[C:25][C:22]3[CH:23]=[CH:24][C:19]([O:18][CH2:17][CH2:16][N:7]4[CH2:8][CH2:9][CH:4]([CH:1]([CH3:3])[CH3:2])[CH2:5][CH2:6]4)=[C:20]([CH3:40])[CH:21]=3)=[N:28][CH:29]=2)=[CH:34][CH:35]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 81531DiisopropylethylamineHCID 140569Piperidine, 4-(1-methylethyl)-HCID 865946832-{4-[5-(4-Chlorophenyl)pyridin-2-ylethynyl]-2-methylphenoxy}ethyl methanesulfonate

生成物 1

HCID 598357425-(4-Chloro-phenyl)-2-{4-[2-(4-isopropyl-piperidin-1-yl)-ethoxy]-3-methyl-phenylethynyl}-pyridine

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

164 mg (1.0 mmol) 4-isopropyl-piperidine (used as the hydrochloride) are added to a solution of 88 mg (0.2 mmol) 2-{4-[5-(4-chloro-phenyl)-pyridin-2-ylethynyl]-2-methyl-phenoxy}-ethyl methanesulphonate and 0.34 mL (2 mmol) ethyldiisopropylamine in 1.8 mL DMF and the reaction mixture is stirred for 24 h at RT. It is filtered using an injection filter and the reaction mixture is purified by HPLC.

後処理

  1. filtrationIt is filtered
  2. filtrationfilter
  3. customthe reaction mixture is purified by HPLC

出典と根拠

ORDレコード
ord-00fad2629e584cde995d3f27007d42fa
出典データセット
uspto-grants-2008_11
特許番号
US07452911B2

関連ノート

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