Sodium Hydroxide → Ethyl (3S)-piperidine-3-carboxylate

HRID 272094

反応式

HRID 272094 の反応式
C(O)(=O)[C@H]([C@@H](C(O)=O)O)O.[NH:11]1[CH2:16][CH2:15][CH2:14][C@H:13]([C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH2:12]1.[OH-].[Na+]>>[NH:11]1[CH2:16][CH2:15][CH2:14][C@H:13]([C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH2:12]1

参加物

3

反応物 2

HCID 14798Sodium HydroxideHCID 14183617Ethyl (S)-3-Piperidinecarboxylate D-Tartrate

生成物 1

HCID 187784Ethyl (3S)-piperidine-3-carboxylate収率 112.8%

実験手順

To 13.0 g of ethyl (3S)-3-piperidinecarboxylate D(−)-tartarate which was synthesized following the method of P. Magnus, et al. [J. Org. Chem. Vol. 56, 1166-1170 (1991)], 3N aqueous sodium hydroxide solution was added to render the former basic, followed by extraction with chloroform and drying over anhydrous magnesium sulfate. Distilling the solvent off under reduced pressure, 7.50 g of the title compound was obtained.

後処理

  1. extractionfollowed by extraction with chloroform
  2. dry with materialdrying over anhydrous magnesium sulfate
  3. distillationDistilling the solvent off under reduced pressure

出典と根拠

ORDレコード
ord-96b0cc3b998343d5bc036a7bcedf6292
出典データセット
uspto-grants-2008_11
特許番号
US07452908B2

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