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2-[(Thiazol-2-yl)methylthio]ethylamine → 3-[2-(2-Thiazolylmethylthio)ethylamino]-6-(3-methoxybenzyl)-1,2,4-triazin-5-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-[(Thiazol-2-yl)methylthio]ethylamine | HCID 12923403 | — |
| 反応物 | 3-Methylthio-6-(3-methoxybenzyl)-1,2,4-triazin-5-one | HCID 135624292 | — |
| 生成物 | 3-[2-(2-Thiazolylmethylthio)ethylamino]-6-(3-methoxybenzyl)-1,2,4-triazin-5-one | HCID 135703224 | 47.6% |
反応手順
3-Methylthio-6-(3-methoxybenzyl)-1,2,4-triazin-5-one (1.18 g) and 2-(2-thiazolylmethylthio)ethylamine (0.87 g) were heated together on an oil bath (160°-70°) for 3/4 hour. The resulting oil, after chromatography and crystallisation from ethanol, gave the title compound as a colourless solid (0.83 g) m.p. 128°-29°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04220767 |
| 出典データセット | uspto-grants-1980_09 |
| ORD ID | ord-91e47578093249e3a13d72b35c15fd5b |
| 出典メモ | uspto-grants-1980_09 |