HCID 45263090、化合物 → 8-Phenyl-1,2,3,4-tetrahydroisoquinoline hydrochloride

HRID 27247ノート

反応式

HRID 27247 の反応式
[ClH:1].C([N:9]1[CH2:18][CH2:17][C:16]2[C:11](=[C:12]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH:13]=[CH:14][CH:15]=2)[CH2:10]1)C1C=CC=CC=1>[Pd].C(O)C>[ClH:1].[C:19]1([C:12]2[CH:13]=[CH:14][CH:15]=[C:16]3[C:11]=2[CH2:10][NH:9][CH2:18][CH2:17]3)[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

参加物

4

反応物 1

HCID 45263090HCID 45263090、化合物

生成物 1

HCID 452657048-Phenyl-1,2,3,4-tetrahydroisoquinoline hydrochloride

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A mixture of 6.20 parts of 2-benzyl-8-phenyl-1,2,3,4-tetrahydroisoquinoline hydrochloride and 0.62 parts of 5% palladium-on-carbon catalyst in 100 parts by volume of ethanol is hydrogenated at 2 psi and ambient temperature for about 6 hours. The filtered reaction solution is concentrated to 75 parts by volume and after the addition of ether crystalline solid is formed. This solid is recrystallized from ethanol to yield 8-phenyl-1,2,3,4-tetrahydroisoquinoline hydrochloride, as white crystals melting at about 268°-270° C. This compound has the following formula ##STR17##

後処理

  1. customThe filtered reaction solution
  2. concentrationis concentrated to 75 parts by volume
  3. additionafter the addition of ether crystalline solid
  4. customis formed
  5. customThis solid is recrystallized from ethanol

出典と根拠

ORDレコード
ord-63e525c625584e91b3679d9e3bb16686
出典データセット
uspto-grants-1980_09
特許番号
US04220778

反応ノート

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