Aripiprazole → Aripiprazole ethylenedichloride

HRID 272579

反応式

HRID 272579 の反応式
[CH:1]1[CH:2]=[C:3]([N:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][O:19][C:20]3[CH:21]=[CH:22][C:23]4[CH2:30][CH2:29][C:27](=[O:28])[NH:26][C:24]=4[CH:25]=3)[CH2:11][CH2:10]2)[C:4]([Cl:8])=[C:5]([Cl:7])[CH:6]=1>C(Cl)CCl>[CH:1]1[CH:2]=[C:3]([N:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][O:19][C:20]3[CH:21]=[CH:22][C:23]4[CH2:30][CH2:29][C:27](=[O:28])[NH:26][C:24]=4[CH:25]=3)[CH2:11][CH2:10]2)[C:4]([Cl:8])=[C:5]([Cl:7])[CH:6]=1.[CH2:4]([Cl:8])[CH2:5][Cl:7]

参加物

3

反応物 1

HCID 60795Aripiprazole

生成物 1

HCID 11489682Aripiprazole ethylenedichloride収率 136.5%

試薬・触媒・溶媒 1

HCID 111,2-Dichloroethane溶媒

反応条件

温度
50 °C

実験手順

Aripiprazole (3 gm) is mixed with ethylenedichloride (30 ml) and heated to 50° C. to form a clear solution. The solution is slowly cooled to 25° C., stirred for 1 hour at about 25° C. and the separated crystals are collected by filtration to give 2.5 gm of aripiprazole ethylenedichloride solvate form V.

後処理

  1. customto form a clear solution
  2. temperatureThe solution is slowly cooled to 25° C.
  3. filtrationthe separated crystals are collected by filtration

出典と根拠

ORDレコード
ord-96181f3c68c34f33896c55e67d1d75aa
出典データセット
uspto-grants-2008_11
特許番号
US07456181B2

関連ノート

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