Triethylamine → (R)-2-(2-Chloro-5-iodo-pyrimidin-4-ylamino)-3-methyl-butan-1-ol
反応式
[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5]([I:9])=[CH:4][N:3]=1.C(N(CC)CC)C.[NH2:17][C@H:18]([CH:21]([CH3:23])[CH3:22])[CH2:19][OH:20]>C(#N)C.O>[Cl:1][C:2]1[N:7]=[C:6]([NH:17][C@H:18]([CH:21]([CH3:23])[CH3:22])[CH2:19][OH:20])[C:5]([I:9])=[CH:4][N:3]=1参加物
6
実験手順
A solution of 10.05 g (36.6 mmol) of 2,4-Dichloro-5-iodo-pyrimidine and 5.6 ml (40.0 mmol) triethylamine in 30 ml of acetonitrile is mixed with 4.85 g (47.0 mmol) of (R)-2-Amino-3-methyl-butan-1-ol. The batch is stirred at room temperature for 16 hours and is finally diluted with water. The batch is filtered and the solid is washed with small amounts of acetonitrile and water. The solid is dried. 10.24 g (30.0 mmol, corresponding to 82% of theory) of the product is obtained.
後処理
- filtrationThe batch is filtered
- washthe solid is washed with small amounts of acetonitrile and water
- customThe solid is dried
- custom10.24 g (30.0 mmol, corresponding to 82% of theory) of the product is obtained
出典と根拠
- ORDレコード
- ord-840b4cd1819e43acb5e41b8f14a7d16d
- 出典データセット
- uspto-grants-2008_11
- 特許番号
- US07456191B2
反応ノート
読み込み中…