Triethylamine → (R)-2-(2-Chloro-5-iodo-pyrimidin-4-ylamino)-3-methyl-butan-1-ol

HRID 272632

反応式

HRID 272632 の反応式
[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5]([I:9])=[CH:4][N:3]=1.C(N(CC)CC)C.[NH2:17][C@H:18]([CH:21]([CH3:23])[CH3:22])[CH2:19][OH:20]>C(#N)C.O>[Cl:1][C:2]1[N:7]=[C:6]([NH:17][C@H:18]([CH:21]([CH3:23])[CH3:22])[CH2:19][OH:20])[C:5]([I:9])=[CH:4][N:3]=1

参加物

6

反応物 3

HCID 8471TriethylamineHCID 2634382,4-Dichloro-5-iodopyrimidineHCID 6950587D-Valinol

生成物 1

HCID 59674020(R)-2-(2-Chloro-5-iodo-pyrimidin-4-ylamino)-3-methyl-butan-1-ol

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6342Acetonitrile溶媒

実験手順

A solution of 10.05 g (36.6 mmol) of 2,4-Dichloro-5-iodo-pyrimidine and 5.6 ml (40.0 mmol) triethylamine in 30 ml of acetonitrile is mixed with 4.85 g (47.0 mmol) of (R)-2-Amino-3-methyl-butan-1-ol. The batch is stirred at room temperature for 16 hours and is finally diluted with water. The batch is filtered and the solid is washed with small amounts of acetonitrile and water. The solid is dried. 10.24 g (30.0 mmol, corresponding to 82% of theory) of the product is obtained.

後処理

  1. filtrationThe batch is filtered
  2. washthe solid is washed with small amounts of acetonitrile and water
  3. customThe solid is dried
  4. custom10.24 g (30.0 mmol, corresponding to 82% of theory) of the product is obtained

出典と根拠

ORDレコード
ord-840b4cd1819e43acb5e41b8f14a7d16d
出典データセット
uspto-grants-2008_11
特許番号
US07456191B2

関連ノート

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