Triethylamine → [1-(5-Bromo-2-chloro-pyrimidin-4-ylamino)-cyclopentyl]-methanol
反応式
[Br:1][C:2]1[C:3](Cl)=[N:4][C:5]([Cl:8])=[N:6][CH:7]=1.C(N(CC)CC)C.[NH2:17][C:18]1([CH2:23][OH:24])[CH2:22][CH2:21][CH2:20][CH2:19]1>C(#N)C>[Br:1][C:2]1[C:3]([NH:17][C:18]2([CH2:23][OH:24])[CH2:22][CH2:21][CH2:20][CH2:19]2)=[N:4][C:5]([Cl:8])=[N:6][CH:7]=1参加物
5
実験手順
An ice-cooled solution of 2.28 g (10.0 mmol) of 5-Bromo-2,4-dichloropyrimidine and 1.7 ml (12.0 mmol) of triethylamine in 10 ml of acetonitrile is mixed with 1.38 g (12.0 mmol) (1-amino-cyclopentyl)-methanol. After 16 hours at room temperature the batch is filtrated to remove the solid precipitate. The precipitate is dried. 1.48 g (4.8 mmol, corresponding to 48% of theory) of the product is obtained.
後処理
- filtrationAfter 16 hours at room temperature the batch is filtrated
- customto remove the solid precipitate
- customThe precipitate is dried
- custom1.48 g (4.8 mmol, corresponding to 48% of theory) of the product is obtained
出典と根拠
- ORDレコード
- ord-4f89754d63b247c6b3faa1cdccff09da
- 出典データセット
- uspto-grants-2008_11
- 特許番号
- US07456191B2
反応ノート
読み込み中…