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2-Naphthaleneacetic acid → HCID 178475060、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Naphthaleneacetic acid | HCID 11393 | — |
| 反応物 | Acetic acid N-hydroxysuccinimide ester | HCID 84460 | — |
| 反応物 | D-Leucine, methyl ester | HCID 89967 | — |
| 反応物 | D(-)-Leucinol | HCID 2724002 | — |
| 反応物 | D-3-(2-Naphthyl)alanine | HCID 2733661 | — |
| 反応物 | (2R)-2-(((tert-butoxy)carbonyl)amino)-3-(naphthalen-2-yl)propanoic acid | HCID 2734481 | — |
| 反応物 | N-{3-[1-[2(R)-Amino-3-naphthalen-2-yl-propionyl]-5(R)-isobutyl-4-(2-naphthalen-2-yl-ethyl)-piperazin-2(S)-yl]-propyl}-guandine | HCID 178445831 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | HCID 178475060 | HCID 178475060 | — |
反応手順
The following compound was synthesized by the method of Scheme 5 using 2-naphthylacetic acid as J-COOH, D-leucinol as NH2—CH(R5)—CH(R4)—OH, D-leucine methyl ester as NH2—CH(R5)—COOCH3, and Boc-D-2-Nal-OH as Q-COOH as described in Example 35. An acetyl group was attached to the amino group of D-2-Nal by reaction of the compound of Example 35 with Ac-OSu in DMF. It was tested as described above with the results shown. The mass was analyzed as 635.9 (M+H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07456184B2 |
| 出典データセット | uspto-grants-2008_11 |
| ORD ID | ord-dd1f7f1ceacf4e9fb4bc41204552fcde |
| 出典メモ | uspto-grants-2008_11 |