huagongshe.com
HRID272652

反应详情

EQUATION

反应方程式

HRID 272652 的结构方程式

REACTANTS

反应物

7
结构：O=C(O)Cc1ccc2ccccc2c1
HCID11393

2-Naphthylacetic acid

C12H10O2

结构：CC(=O)ON1C(=O)CCC1=O
HCID84460

N-Acetoxysuccinimide

C6H7NO4

结构：COC(=O)[C@H](N)CC(C)C
HCID89967

(R)-Methyl 2-amino-4-methylpentanoate

C7H15NO2

结构：CC(C)C[C@@H](N)CO
HCID2724002

(2R)-2-Amino-4-methyl-1-pentanol

C6H15NO

结构：N[C@H](Cc1ccc2ccccc2c1)C(=O)O
HCID2733661

D-3-(2-Naphthyl)alanine

C13H13NO2

结构：CC(C)(C)OC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)O
HCID2734481

Boc-3-(2-naphthyl)-D-alanine

C18H21NO4

结构：CC(C)C[C@@H]1CN(C(=O)[C@H](N)Cc2ccc3ccccc3c2)[C@@H](CCCNC(=N)N)CN1CCc1ccc2ccccc2c1
HCID178445831

未命名化合物

PRODUCTS

生成物

1
结构：CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N1C[C@@H](CC(C)C)N(CCc2ccc3ccccc3c2)C[C@@H]1CCCNC(=N)N
HCID178475060

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

The following compound was synthesized by the method of Scheme 5 using 2-naphthylacetic acid as J-COOH, D-leucinol as NH2—CH(R5)—CH(R4)—OH, D-leucine methyl ester as NH2—CH(R5)—COOCH3, and Boc-D-2-Nal-OH as Q-COOH as described in Example 35. An acetyl group was attached to the amino group of D-2-Nal by reaction of the compound of Example 35 with Ac-OSu in DMF. It was tested as described above with the results shown. The mass was analyzed as 635.9 (M+H).