5-Bromo-8-nitroisoquinoline → 5-Bromoisoquinolin-8-amine

HRID 272775

反応式

HRID 272775 の反応式
[Br:1][C:2]1[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[C:8]2[C:3]=1[CH:4]=[CH:5][N:6]=[CH:7]2.[H][H]>[Pt].C(O)(=O)C>[Br:1][C:2]1[CH:11]=[CH:10][C:9]([NH2:12])=[C:8]2[C:3]=1[CH:4]=[CH:5][N:6]=[CH:7]2

参加物

5

反応物 2

HCID 8169835-Bromo-8-nitroisoquinolineHCID 178418361HCID 178418361、化合物

生成物 1

HCID 162183025-Bromoisoquinolin-8-amine収率 60%

試薬・触媒・溶媒 2

HCID 23939Platinum触媒HCID 176Acetic Acid溶媒

実験手順

A mixture of Example 801A (500 mg, 2 mmol), 5% Pt/C and acetic acid (50 mL) was equipped with a balloon of hydrogen gas and stirred at room temperature. When the reaction was complete, the solution was filtered through Celite. The mixture was treated with 50% sodium hydroxide solution until pH reached 10. Filtration provided 267 mg (60%) of the desired product as a yellow solid. MS (ESI) m/e 223 (M+H)+.

後処理

  1. filtrationthe solution was filtered through Celite
  2. additionThe mixture was treated with 50% sodium hydroxide solution until pH
  3. filtrationFiltration

出典と根拠

ORDレコード
ord-edf2fdf58e13430cb897e04894003c20
出典データセット
uspto-grants-2008_11
特許番号
US07456169B2

関連ノート

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