Ammonium Hydroxide → 1-(3-Cyanophenyl)urea
反応式
[C:1]([C:3]1[CH:4]=[C:5]([N:9]=[C:10]=[O:11])[CH:6]=[CH:7][CH:8]=1)#[N:2].[OH-].[NH4+:13]>C1COCC1>[C:1]([C:3]1[CH:4]=[C:5]([NH:9][C:10]([NH2:13])=[O:11])[CH:6]=[CH:7][CH:8]=1)#[N:2]参加物
4
実験手順
To 3-cyanophenyl isocyanate (1.0 g, 6.90 mmol) in THF (5 mL), ammonium hydroxide (1.7 mL, 13.8 mmol) was added. The reaction was stirred for 2 h at rt. The solvent was evaporated and the crude residue was redissolved in ethyl acetate. The organic layer was washed with water and brine and dried over sodium sulfate. The solvent was evaporated and the crude residue was purified by flash column chromatography to 41A (0.37 g).
後処理
- customThe solvent was evaporated
- dissolutionthe crude residue was redissolved in ethyl acetate
- washThe organic layer was washed with water and brine
- dry with materialdried over sodium sulfate
- customThe solvent was evaporated
- customthe crude residue was purified by flash column chromatography to 41A (0.37 g)
出典と根拠
- ORDレコード
- ord-cc36db0608964e15b7d2f4c53ebf0783
- 出典データセット
- uspto-grants-2008_11
- 特許番号
- US07456195B2
反応ノート
読み込み中…