Thionyl Chloride → HCID 68576193、化合物

HRID 272994ノート

反応式

HRID 272994 の反応式
[CH:1]([N:14]1[CH2:17][CH:16]([CH2:18]O)[CH2:15]1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(Cl)([Cl:22])=O>ClCCl>[ClH:22].[CH:1]([N:14]1[CH2:17][CH:16]([CH2:18][Cl:22])[CH2:15]1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 2758715(1-Benzhydrylazetidin-3-yl)methanol

生成物 1

HCID 68576193HCID 68576193、化合物収率 168.9%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
2.5 °C

実験手順

(1-Benzhydryl-azetidin-3-yl)-methanol (3.07 g, 12.1 mmol) was dissolved in dichloromethane (60 ml). The reaction was cooled to 0-5° C. and thionyl chloride (1.07 ml, 14.6 mmol) was added slowly. The reaction was allowed to warm to room temperature and stirred for 18 hours. The reaction was concentrated in vacuo and azeotroped with toluene (3×20 ml) to give the title compound (3.8 g, 100%) as a pale brown solid.

後処理

  1. temperatureto warm to room temperature
  2. concentrationThe reaction was concentrated in vacuo
  3. customazeotroped with toluene (3×20 ml)

出典と根拠

ORDレコード
ord-487dd085125e4edcbd1de025078c0b97
出典データセット
uspto-grants-2008_11
特許番号
US07456164B2

反応ノート

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