Thionyl Chloride → trans-1-Chloro-3-(3-ethyl-1-methylcyclobutyl)-prop-1-en-3-one
反応式
O[CH:2]=[CH:3][C:4]([C:6]1([CH3:12])[CH2:9][CH:8]([CH2:10][CH3:11])[CH2:7]1)=[O:5].S(Cl)([Cl:15])=O>C1C=CC=CC=1>[Cl:15]/[CH:2]=[CH:3]/[C:4]([C:6]1([CH3:12])[CH2:9][CH:8]([CH2:10][CH3:11])[CH2:7]1)=[O:5]参加物
4
実験手順
A solution of 5.8 g of 1-hydroxy-3-(3-ethyl-1-methylcyclobutyl)-prop-1-en-3-one (prepared in Example 4A) in 100 ml of benzene was stirred under an argon atmosphere and 7 ml of thionyl chloride in 10 ml of benzene was added dropwise. The resulting solution was stirred for about 15 hr. Excess solvent was removed by distillation at atmospheric pressure and the residue was then distilled in vacuo to yield 4.2 g of the title compound having the following physical characteristics:
後処理
- customExcess solvent was removed by distillation at atmospheric pressure
- distillationthe residue was then distilled in vacuo
出典と根拠
- ORDレコード
- ord-dfce49b24eef4f29acfdd572bdff2687
- 出典データセット
- uspto-grants-1980_09
- 特許番号
- US04220795
反応ノート
読み込み中…