Thionyl Chloride → trans-1-Chloro-3-(3-ethyl-1-methylcyclobutyl)-prop-1-en-3-one

HRID 27300

反応式

HRID 27300 の反応式
O[CH:2]=[CH:3][C:4]([C:6]1([CH3:12])[CH2:9][CH:8]([CH2:10][CH3:11])[CH2:7]1)=[O:5].S(Cl)([Cl:15])=O>C1C=CC=CC=1>[Cl:15]/[CH:2]=[CH:3]/[C:4]([C:6]1([CH3:12])[CH2:9][CH:8]([CH2:10][CH3:11])[CH2:7]1)=[O:5]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 705764901-Hydroxy-3-(3-ethyl-1-methylcyclobutyl)-prop-1-en-3-one

生成物 1

HCID 23344457trans-1-Chloro-3-(3-ethyl-1-methylcyclobutyl)-prop-1-en-3-one

試薬・触媒・溶媒 1

HCID 241Benzene溶媒2 回

実験手順

A solution of 5.8 g of 1-hydroxy-3-(3-ethyl-1-methylcyclobutyl)-prop-1-en-3-one (prepared in Example 4A) in 100 ml of benzene was stirred under an argon atmosphere and 7 ml of thionyl chloride in 10 ml of benzene was added dropwise. The resulting solution was stirred for about 15 hr. Excess solvent was removed by distillation at atmospheric pressure and the residue was then distilled in vacuo to yield 4.2 g of the title compound having the following physical characteristics:

後処理

  1. customExcess solvent was removed by distillation at atmospheric pressure
  2. distillationthe residue was then distilled in vacuo

出典と根拠

ORDレコード
ord-dfce49b24eef4f29acfdd572bdff2687
出典データセット
uspto-grants-1980_09
特許番号
US04220795

関連ノート

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