Triethylamine → 2-Methylpyridine-4-carboxylic acid
反応式
[H][H].Cl[C:4]1[CH:9]=[C:8]([C:10]([OH:12])=[O:11])[CH:7]=[C:6]([CH3:13])[N:5]=1.C(N(CC)CC)C>[Pd].C(O)C>[CH3:13][C:6]1[N:5]=[CH:4][CH:9]=[C:8]([C:10]([OH:12])=[O:11])[CH:7]=1参加物
6
実験手順
A hydrogen filled balloon was attached to a flask containing 2-chloro-6-methylpyridine-4-carboxylic acid (2 g, 12.0 mmol), palladium 10 wt. % on activated carbon (0.5 g), triethyl amine (4.8 ml) and ethanol (24 ml) and then stirred overnight at room temperature. The is reaction mixture was filtered through celite, washed with methanol and concentrated. The residue was titurated with dichloromethane and then filtered to afford 6-methylpyridine-4-carboxylic acid as a white solid; 1.05 g (66%). 1H NMR (MeOD) δ (ppm): 8.62 (d, 1H), 7.68 (s, 1H), 7.60 (d, 1H), 2.55 (s, 3H).
後処理
- customThe is reaction mixture
- filtrationwas filtered through celite
- washwashed with methanol
- concentrationconcentrated
- filtrationfiltered
出典と根拠
- ORDレコード
- ord-3db16f75d17b4f68b39d141a45c58893
- 出典データセット
- uspto-grants-2008_11
- 特許番号
- US07456200B2
反応ノート
読み込み中…