HCID 58938153、化合物 → Benzoic acid, 3-fluoro-5-methyl-, methyl ester
反応式
[CH3:1][O:2][C:3](=[O:13])[C:4]1[CH:9]=[C:8]([CH2:10]O)[CH:7]=[C:6]([F:12])[CH:5]=1>[Pd].C(O)C>[CH3:1][O:2][C:3](=[O:13])[C:4]1[CH:9]=[C:8]([CH3:10])[CH:7]=[C:6]([F:12])[CH:5]=1参加物
4
実験手順
Ethanol (2 ml) was added to round bottom flask containing 3-fluoro-5-hydroxymethyl-benzoic acid methyl ester (667 mg, 3.6 mmol) and palladium (10 wt. % on activated carbon, 300 mg) under argon. The flask was evacuated using a water aspirator and then filled with hydrogen from a balloon. After stirring for 2 h, the palladium on carbon was removed by filtration through celite. The filtrate was then concentrated to afford 520 mg (87%) of 3-fluoro-5-methyl-benzoic acid methyl ester. 1H NMR (CDCl3), δ (ppm): 7.65 (s, 1H), 7.51 (d, 1H), 7.08 (d, 1H), 3.91 (s, 3H), 2.40 (s, 3H).
後処理
- customThe flask was evacuated
- additionfilled with hydrogen from a balloon
- customthe palladium on carbon was removed by filtration through celite
- concentrationThe filtrate was then concentrated
出典と根拠
- ORDレコード
- ord-a5bb3d3a018a431f9047483cc65801ce
- 出典データセット
- uspto-grants-2008_11
- 特許番号
- US07456200B2
反応ノート
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