Hydrazine hydrate (1:1) → 2-Methylisonicotinic acid hydrazide

HRID 273114

反応式

HRID 273114 の反応式
C[O:2][C:3](=O)[C:4]1[CH:9]=[CH:8][N:7]=[C:6]([CH3:10])[CH:5]=1.O.[NH2:13][NH2:14]>>[CH3:10][C:6]1[CH:5]=[C:4]([CH:9]=[CH:8][N:7]=1)[C:3]([NH:13][NH2:14])=[O:2]

参加物

3

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 11542811Methyl 2-methylisonicotinate

生成物 1

HCID 3225492-Methylisonicotinic acid hydrazide収率 86%

実験手順

2-Methyl-isonicotinic acid methyl ester (316.5 mg, 2.093 mmol) was dissolved in MEOH (7 mL) under Argon and hydrazine monohydrate 98% (1 mL, 20.93 mmol) was added. The reaction was allowed to stir under Argon at room temperature for eighteen hours. The reaction was concentrated to give the title compound (271.9 mg, 86%) as a white solid. 1H NMR CDCl3 δ (ppm): 8.59 (d, 1H), 7.50 (s, 1H), 7.38 (d, 1H), 3.09 (br. s, 3H), 2.60 (s, 3H).

後処理

  1. concentrationThe reaction was concentrated

出典と根拠

ORDレコード
ord-25c6d70903484f04990a3df67aeb4b3f
出典データセット
uspto-grants-2008_11
特許番号
US07456200B2

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