1-(6-Methoxy-benzofuran-3-yl)-ethane-1,2-diol → 6-Methoxybenzofuran-3-carbaldehyde
反応式
[CH3:1][O:2][C:3]1[CH:15]=[CH:14][C:6]2[C:7]([CH:10]([OH:13])CO)=[CH:8][O:9][C:5]=2[CH:4]=1>C1COCC1.O>[CH3:1][O:2][C:3]1[CH:15]=[CH:14][C:6]2[C:7]([CH:10]=[O:13])=[CH:8][O:9][C:5]=2[CH:4]=1参加物
4
実験手順
NaIO4 (0.204 g, 1.12 mmol) was added to 1-(6-methoxy-benzofuran-3-yl)-ethane-1,2-diol (0.180 g, 1.196 mmol) in THF (50 mL) and water (1 mL) with stirring. The mixture was stirred overnight at room temperature under N2. Water (10 mL) was added, and the mixture was concentrated to half its volume and extracted with EtOAc. The organic layer was washed with brine and water, dried over anhyd. MgSO4, and evaporated to give a residue, which was purified on a silica gel column eluting with EtOAc/hexane (1:10) to give 6-methoxybenzofuran-3-carbaldehyde (0.110 g, 73%).
後処理
- stirringThe mixture was stirred overnight at room temperature under N2
- concentrationthe mixture was concentrated to half its volume
- extractionextracted with EtOAc
- washThe organic layer was washed with brine and water
- customdried over anhyd
- customMgSO4, and evaporated
- customto give a residue, which
- customwas purified on a silica gel column
- washeluting with EtOAc/hexane (1:10)
出典と根拠
- ORDレコード
- ord-48aeedf470cd4b08826f5be8112c6084
- 出典データセット
- uspto-grants-2008_11
- 特許番号
- US07456289B2
反応ノート
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