Ethylene Glycol → 3-(1,3-Dioxolan-2-yl)-6-methoxybenzofuran
反応式
[CH3:1][O:2][C:3]1[CH:13]=[CH:12][C:6]2[C:7]([CH:10]=[O:11])=[CH:8][O:9][C:5]=2[CH:4]=1.[OH:14][CH2:15][CH2:16]O.O>C1C=CC=CC=1>[O:11]1[CH2:16][CH2:15][O:14][CH:10]1[C:7]1[C:6]2[CH:12]=[CH:13][C:3]([O:2][CH3:1])=[CH:4][C:5]=2[O:9][CH:8]=1参加物
5
実験手順
A mixture of 6-methoxybenzofuran-3-carbaldehyde (0.600 g, 3.41 mmol), HOCH2CH2OH (3.17 g, 51 mmol) and p-toluenesulfonic acids (0.001 g) in benzene (20 mL) was refluxed for 8 h using a Dean-Stark water trap. The mixture was concentrated under reduced pressure and then diluted with EtOAc. The organic solution was washed with water, dried over anhydrous MgSO4, and concentrated to give 3-(1,3-dioxolan-2-yl)-6-methoxybenzofuran (0.711 g, 95%)
後処理
- temperaturewas refluxed for 8 h
- concentrationThe mixture was concentrated under reduced pressure
- additiondiluted with EtOAc
- washThe organic solution was washed with water
- dry with materialdried over anhydrous MgSO4
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-b85f95c64a904ebdba1cf6a4ca14aca7
- 出典データセット
- uspto-grants-2008_11
- 特許番号
- US07456289B2
反応ノート
読み込み中…