4-chloro-2-methoxy-7H-pyrrolo[2,3-d]pyrimidine → 2-methoxy-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine

HRID 273346ノート

反応式

HRID 273346 の反応式
Cl[C:2]1[C:3]2[CH:12]=[CH:11][NH:10][C:4]=2[N:5]=[C:6]([O:8][CH3:9])[N:7]=1>CO.[Pd]>[CH3:9][O:8][C:6]1[N:7]=[CH:2][C:3]2[CH2:12][CH2:11][NH:10][C:4]=2[N:5]=1

参加物

4

反応物 1

HCID 61402294-chloro-2-methoxy-7H-pyrrolo[2,3-d]pyrimidine

生成物 1

HCID 691945832-methoxy-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

10% Pd/C (1.000 g, 11.6 mmol) was added to a solution of 4-chloro-2-methoxy-7H-pyrrolo[2,3-d]pyrimidine (0.200 g, 1.09 mmol) in 20 mL anhydrous MeOH under H2 at room temperature. The mixture was stirred for 8 h and then filtered through a pad of Celite. The filtrate was concentrated in vacuo to give 2-methoxy-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine as a major product.

後処理

  1. filtrationfiltered through a pad of Celite
  2. concentrationThe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-aa4022a2d60a4ba2a1e21abc1f0f0068
出典データセット
uspto-grants-2008_11
特許番号
US07456289B2

反応ノート

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