関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-Ethyl-6-methylaniline | HCID 32485 | — |
| 反応物 | 4-(Chloromethyl)-1,3-thiazole | HCID 2763290 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | N-(thiazol-4-yl)methyl-2-ethyl-6-methylaniline | HCID 20534534 | 39.7% |
反応手順
In 200 ml dry dimethylformamide was added 10.2 g 4-chloromethylthiazole, 10.26 g 2-ethyl-6-methylaniline and 10.54 g of potassium carbonate. The mixture was stirred at 100° C. for 3 days and filtered. The filtrate was stripped, dissolved in methylene chloride, washed with water, dried and stripped again. The crude product was chromatographed with methylene chloride through a 200-g silica-gel column to give 7 g of product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04221584 |
|---|
| 出典データセット | uspto-grants-1980_09 |
|---|
| ORD ID | ord-b9e27a171eb14d4e9634988a95ba4bfe |
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| 出典メモ | uspto-grants-1980_09 |
|---|
