反应详情

温度

100 °C

In 200 ml dry dimethylformamide was added 10.2 g 4-chloromethylthiazole, 10.26 g 2-ethyl-6-methylaniline and 10.54 g of potassium carbonate. The mixture was stirred at 100° C. for 3 days and filtered. The filtrate was stripped, dissolved in methylene chloride, washed with water, dried and stripped again. The crude product was chromatographed with methylene chloride through a 200-g silica-gel column to give 7 g of product.

1. filtrationfiltered
2. dissolutiondissolved in methylene chloride
3. washwashed with water
4. customdried
5. customThe crude product was chromatographed with methylene chloride through a 200-g silica-gel column