化工社化工社 化学情報印刷レポート · 研究参考用
Ethanol → Perindopril Erbumine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | (2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)butyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic Acid Benzyl Ester | HCID 71751530 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 生成物 | Perindopril Erbumine | HCID 441313 | — |
反応手順
Perindopril benzyl ester (1.4 g) obtained in Step VI was dissolved in absolute ethanol (15 ml). To the solution was added 10% Pd—C (5% w/w) and the mixture hydrogenated at 20-22° C. for 3 hours till completion of the reaction. The catalyst was filtered off and the filtrate concentrated under reduced pressure at 45° C. to give 1.3 g of perindopril (II).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07456296B2 |
| 出典データセット | uspto-grants-2008_11 |
| ORD ID | ord-186f8441299847c0be7a5e501179832f |
| 出典メモ | uspto-grants-2008_11 |