Iodoethane → 5-(4-cyanophenyl)-N-ethyl-N-(4-(piperazin-1-yl)phenyl)furan-2-carboxamide

HRID 273599ノート

反応式

HRID 273599 の反応式
CCI.CC(C)(C)OC(=O)N1CCN(c2ccc(NC(=O)c3ccc(-c4ccc(C#N)cc4)o3)cc2)CC1>O=S(=O)(O)O.[Li]N([Si](C)(C)C)[Si](C)(C)C.CN(C)C=O.CN(C)C=O.CN(C)C=O.COCCOCCOC>CC(C)(C)OC(=O)N1CCN(c2ccc(NC(=O)c3ccc(-c4ccc(C#N)cc4)o3)cc2)CC1.CC(C)(C)OC(=O)N1CCN(c2ccc(NC(=O)c3ccc(-c4ccc(C#N)cc4)o3)cc2)CC1.CCN(C(=O)c1ccc(-c2ccc(C#N)cc2)o1)c1ccc(N2CCNCC2)cc1

参加物

8

反応物 2

HCID 6340IodoethaneHCID 168301699Tert-butyl 4-(4-(5-(4-cyanophenyl)furan-2-carboxamido)phenyl)piperazine-1-carboxylate

生成物 2

HCID 168301699Tert-butyl 4-(4-(5-(4-cyanophenyl)furan-2-carboxamido)phenyl)piperazine-1-carboxylate2 回HCID 1683017115-(4-cyanophenyl)-N-ethyl-N-(4-(piperazin-1-yl)phenyl)furan-2-carboxamide収率 46%

試薬・触媒・溶媒 4

HCID 1118Sulfuric Acid試薬HCID 178418261HCID 178418261、化合物試薬HCID 6228Dimethylformamide溶媒3 回HCID 8150Diglyme溶媒

反応条件

温度
23 °C

後処理

  1. additionquenched by addition of saturated aqueous NaHCO3 (2 uL) and diluted with water (1 uL) and DMSO (2 uL)
  2. additionquenched by addition of saturated aqueous NaHCO3 (2 uL) and diluted with water (1 uL) and DMSO (2 uL)
  3. additionquenched by addition of saturated aqueous NaHCO3 (2 uL) and diluted with water (1 uL) and DMSO (2 uL)
  4. additionThe reactions were further diluted to 10 mM using DMSO.

出典と根拠

ORDレコード
ord-44e376048cfc45a4ac83424afdb074cc
出典データセット
Cernak miniaturized N-alkylation with BOC deprotection
元リンク
出典を表示

反応ノート

読み込み中…