Thionyl Chloride → HCID 19351525、化合物
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][N:9]1[C:13]([CH2:14]O)=[CH:12][N:11]=[C:10]1[S:16][CH2:17][CH2:18][CH3:19].S(Cl)([Cl:22])=O>>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][N:9]1[C:13]([CH2:14][Cl:22])=[CH:12][N:11]=[C:10]1[S:16][CH2:17][CH2:18][CH3:19]参加物
3
実験手順
A mixture of 1-(2-chlorophenyl)methyl-5-hydroxymethyl-2-propylthio-1H-imidazole (0.117 g, 0.393 mmol) in thionyl chloride (1 mL) was refluxed for 2 hours, evaporated in vacuo to an amorphous solid and triturated with ether to provide 1-(2-chlorophenyl)methyl-5-chloromethyl-2-propylthio-1H-imidazole hydrochloride (0.13 g, 94%).
後処理
- temperaturewas refluxed for 2 hours
- customevaporated in vacuo to an amorphous solid
- customtriturated with ether
出典と根拠
- ORDレコード
- ord-d385dd307fa840f4aa2ece2221ee61c6
- 出典データセット
- uspto-grants-1995_02
- 特許番号
- US05387601
反応ノート
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