Hydrochloric Acid → 1-(2-Bromoethoxy)-2-(2,2,2-trifluoroethoxy)benzene
反応式
[OH-].[Na+].[F:3][C:4]([F:15])([F:14])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[OH:13].[Br:16][CH2:17][CH2:18]Br.Cl>>[Br:16][CH2:17][CH2:18][O:13][C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=1[O:6][CH2:5][C:4]([F:14])([F:15])[F:3]参加物
5
反応条件
- 温度
- 120 °C
実験手順
To an aqueous solution (15 ml) of sodium hydroxide (0.63 g) were added 2-(2,2,2-trifluoroethoxy)phenol (2.85 g) and 1,2-dibromoethane (1.68 ml), and the mixture was reacted with stirring at 120° C. for 8 hours. To the reaction mixture was added concentrated hydrochloric acid (1.3 ml), and the mixture was extracted with diethyl ether. The extract was washed with water, dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by medium pressure liquid column chromatography on silica gel using a mixture of hexane and diethyl ether (5/1) as eluent to give 1.78 g of 1-(2-bromoethoxy)-2-(2,2,2-trifluoroethoxy)benzene as an oil
後処理
- customthe mixture was reacted
- extractionthe mixture was extracted with diethyl ether
- washThe extract was washed with water
- dry with materialdried over anhydrous magnesium sulfate
- customThe solvent was evaporated under reduced pressure
- customthe residue was purified by medium pressure liquid column chromatography on silica gel using
- additiona mixture of hexane and diethyl ether (5/1) as eluent
出典と根拠
- ORDレコード
- ord-8817aab7fb0d4d6991795a0999b606a8
- 出典データセット
- uspto-grants-1995_02
- 特許番号
- US05387603
反応ノート
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